News

Exchanges

• Bittrex delsited FLDC because we could not provide Liechtenstein legal opinions paperwork. The paperwork cost was too expensive for us.
You must withdraw your FLDC from bittrex, the deadline April 3, 2020 at 07:01 UTC!
In the meantime https://freewallet.io/ can provide decentralized exchange functions for FLDC and any counterparty assets (btc fee required to trade or put up orders)
https://bittrexglobal.zendesk.com/hc/en-us/articles/360012117260-Wallet-Removal-on-April-3-2020

• ChainRift is closing down its exchange operation & pivoting to a software development company
https://medium.com/chainrift/chainrift-is-closing-down-its-exchange-operation-pivoting-to-a-software-development-company-9e99c876bd12

 

Special news

Source: 
https://foldingathome.org/2020/03/15/coronavirus-what-were-doing-and-how-you-can-help-in-simple-terms/

Interesting articles:
https://foldingathome.org/2020/03/10/covid19-update/
https://www.coindesk.com/thousands-of-these-computers-were-mining-cryptocurrency-now-theyre-working-on-coronavirus-research
https://www.reddit.com/r/pcmasterrace/comments/flgm7q/ama_with_the_team_behind_foldinghome_coronavirus/
https://onezero.medium.com/you-can-help-fight-coronavirus-by-giving-scientists-access-to-your-computer-16c39c2e7164

 

Coronavirus - What we are doing and how you can help in simple terms

• Proteins are molecular machines that perform many functions we associate with life. They sense the environment (e.g. in taste and smell), perform work (e.g. muscle contraction and breaking down food), and play structural roles (e.g. your hair). They are made of a linear chain of chemicals called amino acids that, in many cases, spontaneously “fold” into compact, functional structures. Much like any other machine, it’s how a protein’s components are arranged and move that determine the protein’s function. In this case, the components are atoms.
• Viruses also have proteins that they use to suppress our immune systems and reproduce themselves.
• To help tackle coronavirus, we want to understand how these viral proteins work and how we can design therapeutics to stop them.
 • There are many experimental methods for determining protein structures. While extremely powerful, they only reveal a single snapshot of a protein’s usual shape. But proteins have lots of moving parts, so we really want to see the protein in action. The structures we can’t see experimentally may be the key to discovering a new therapeutic.
• Using football as an analogy for the experimental situation, it’s as if you could only see the players lined up for the snap (the single arrangement the players spend the most time in) and were blind to the rest of the game.

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• Seeing a single structure of a protein (left) is like seeing players lined up for the snap in football. Important information, but a lot missing too. The protein structure shows a sphere for each atom (blue) and red arrows highlighting the one drug binding site in this protein.
• Our specialty is in using computer simulations to understand proteins’ moving parts. Watching how the atoms in a protein move relative to one another is important because it captures valuable information that is inaccessible by any other means.
• Taking the experimental structures as starting points, we can simulate how all the atoms in the protein move, effectively filling in the rest of the game that experiments miss.
 
• A movie capturing how the protein shown before moves is like getting to watch the whole football game. In this case, we see a pocket form that was absent in the experimental structure.
• Doing so can reveal new therapeutic opportunities. For example, in our recent paper, we simulated a protein from Ebola virus that is typically considered ‘undruggable’ because the snapshots from experiments don’t have obvious druggable sites. But, our simulations uncovered an alternative structure that does have a druggable site. Importantly, we then performed experiments that confirmed our computational prediction, and are now searching for drugs that bind this newly discovered binding site.
 
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• An experimental structure of an Ebola protein doesn’t have obvious druggable sites (no deep pockets among the atoms shown as spheres).
• Our simulations captured a motion that creates a potentially druggable site in this Ebola protein. Instead of showing spheres for each atom, this cartoon shows a ribbon tracing the linear chain of amino acids (chemicals) the protein is made of.
• We want to do the same thing with coronavirus, and you can help! In fact, there are a number of ways you can help, and they’re not mutually exclusive.

 

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